Introducing Orion™ HT

The first high-plex spatial proteomics platform designed for clinical scale



Speak with a specialist
20

Channels in single round

100+

Slides per week

30

Slide automation

24/7

Unattended operation

The Orion HT is the newest instrument in the Orion portfolio, purpose-built for clinical-scale biomarker programs and multi-user environments. It delivers high-plex, high-throughput, and high-capacity spatial proteomics with 24/7 hands-off operation enabled by 30-slide automation. Users have continuous access to add and remove slides and prioritize scan order, and barcode-driven workflows maintain sample custody throughout.

Powered by paradigm-shifting 20-channel whole slide scanning, it uniquely combines these capabilities with the accuracy and reproducibility required to turn spatial insights into clinical impact.


The Orion single-round high-plex advantage


With single-round cocktail staining and imaging across 20 channels in a single round, Orion delivers the biomarker depth, throughput, panel flexibility, and data quality that clinical and translational research demands.

Biomarker Depth

  • Resolve tissue microenvironments with panels incorporating phenotypic, functional and structural biomarkers
  • Preserve precious clinical samples by measuring multiple predictive and prognostic markers on a single tissue section

High Throughput

  • High-capacity automation and parallel workflow for large cohort studies and multi-user environments
  • Scalable platform supporting biomarker development from validation through clinical trials
  • Ultra-high-speed scanning for whole slide and high volume

Rapid, Flexible Panel Development

  • Extensive portfolio of Orion antibody conjugates — assemble in any combination
  • Simple conjugation chemistry enables easy incorporation of your custom biomarkers
  • Single-round staining eliminates staining order complexity, accelerating panel development

Quantitative Data You Can Trust

  • Single-round staining preserves tissue and antigen integrity
  • Ultra-bright dyes combined with high-powered laser excitation ensures detection of low expression biomarkers
  • Standard pathology protocols and direct conjugate staining ensures reproducible results

"We are excited to offer multiplex immunofluorescence for clinical trial biomarker testing leveraging the powerful Orion HT technology. As pioneers in multiplex immunofluorescence for clinical trials, this technology will enable us to efficiently run 18-plex assays in a regulated setting."

Jennifer Bordeaux, PhD

Associate Director, Digital Pathology Solutions, Navigate Biopharma Services, Inc.


Learn how Navigate Biopharma validated a 17-plex panel for clinical trials ➝

Ready to see what Orion HT can do for your spatial biomarker program?



Contact us Learn more about the Orion platform