Orion™ Panels
Colorectal Cancer (CRC)
This is a sample of Orion imaging utilizing an Orion biomarker panel. Whole-slide tissue section of an invasive colorectal adenocarcinoma was stained with a 17-plex immuno-oncology biomarker panel and imaged with the Orion system in a single staining and imaging process.
- Only non-cyclic spatial biology system for translational through clinical studies.
- 17-plex – stain all in a single cocktail and add to your slide, image all channels and all biomarkers at the same time, one time.
- No Cycling. No tissue degradation, save your precious sample.
- Large tissue sections, two small tissue sections on one slide, the largest whole slide area
- Little hands-on time, stain all at once, one time, AND image all channels/markers at the same time, one time – accelerate sample to data timing.
- No special coverslips. Use std IHC tools you already have. Bench top size.
- Choose an off-the-shelf panel or easily customize to your needs by removing/adding markers of your choice.
- Nucleus (Hoescht)
- Autofluorescence
- CD31
- CD45
- CD68
- CD4
- FOXP3
- CD8a
- CD45RO
- CD20
- PD-L1
- CD3e
- CD163
- E-Cadherin
- PD-1
- Ki67
- Pan-CK
- Smooth Muscle Actin
A Harvard study describes an approach for combining same-slide H&E and high-plex immunofluorescence (IF) data in a whole-slide format to elucidate prognostic biomarkers for CRC patient survival or disease recurrence.
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This Weill Cornell Medicine study observes patient samples in a neoadjuvant trial delivering rapid response information and shows potential to inform mechanisms of therapeutic action, providing real-time insight for clinical trial design.
Read the study ➝