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Publications and Posters

Featured Publication

SARS-CoV-2 infection protects against rechallenge in rhesus macaques



CyCIF experiments imaged on the CyteFinder Instrument played a key role in understanding SARS-CoV-2 infection and immune response.

A. Chandrashekar, J. Liu, A. Martinot, et al.
Science 2020; eabc4776.
DOI: 10.1126/science.abc4776

Select Publications

A single-cell landscape of high-grade serous ovarian cancer
B. Izar, I. Tirosh, E. H. Stover, et al.
Nature Medicine. 2020; DOI: 10.1038/s41591-020-0926-0.
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SARS-CoV-2 infection protects against rechallenge in rhesus macaques
A. Chandrashekar, J. Liu, A. Martinot, et al.
Science. 2020; DOI: 10.1126/science.abc4776.
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Circulating tumor cell investigation in breast cancer patient-derived xenograft models by automated immunofluorescence staining, image acquisition, and single cell retrieval and analysis
Ramirez A, Bhat R, Sahay D, et al.
BMC Cancer. 2019; 19 (220): 1-10.
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PIC&RUN: An integrated assay for the detection and retrieval of single viable circulating tumor cells
Kamal M, Saremi S, Klotz R, et al.
SciRep. 2019; 9(17470): 1-10.
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Validation Studies for Single Circulating Trophoblast Genetic Testing as a Form of Noninvasive Prenatal Diagnosis
Vossaert L, Wang Q, Salman R, et al.
AJHG. 2019; 105: 1-12
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A Rapid Method for Label-Free Enrichment of Rare Trophoblast Cells from Cervical Samples
Bailey-Hytholt C, Sayeed S, Kraus M, et al.
SciRep. 2019; 9(12115): 1-10.
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A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade
L Jerby-Arnon, P Shah, M Cuoco, et al.
Cell. 2018; 175(4): 984-997.
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The RareCyte® Platform for Next-Generation Analysis of Circulating Tumor Cells
Kaldjian, E, Ramirez A, Sun Y, et al.
Cytometry Part A. 2018; 93A: 1220-1225.
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Reliable detection of subchromosomal deletions and duplications using cell-based noninvasive prenatal testing
Vossaert L, Wang Q, Salman R, et al.
Prenat Diagn. 2018; 38: 1069-1078.
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Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes
Lin J, Izar B, Wang S, et al.
Elife. 2018; e31657: 1-46.
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Prostate cancer disseminated tumor cells are rarely detected in the bone marrow of patients with localized disease undergoing radical prostatectomy across multiple rare cell detection platforms
Chalfin H, Glavaris S, Malihi P, et al.
J Urol. 2018; 199(6): 1494-1501.
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A distributed network for intensive longitudinal monitoring in metastatic triple-negative breast cancer
Blau C, Ramirez A, Blau S, et al.
J Natl Compr Canc Netw. 2016; 14(1): 8-17.
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Evidence for feasibility of fetal trophoblastic cell-based noninvasive prenatal testing
Breman A, Chow J, U’Ren L, et al.
Prenat Diagn. 2016; 36(11): 1009-1019.
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Nucleolin staining may aid in the identification of circulating prostate cancer cells
Chalfin H, Verdone, V, van der Toom E, Glavaris S, Gorin M, Pienta K.
Clin Genitourin Cancer. 2016; 15(3): 477-481.
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High-recovery visual identification and single-cell retrieval of circulating tumor cells for genomic analysis using a dual-technology platform integrated with automated immunofluorescence staining
Campton D, Ramirez A, Nordberg J, et al.
BMC Cancer. 2015; 15(360): 1-13.
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Select Posters

A multiparameter assay for HER2 protein detection on circulating tumor cells in non-small cell lung cancer
Presented at AACR 2020
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Investigation of custom biomarkers on circulating tumor cells from clinical samples using RarePlex Developer Kits
Presented at AACR 2020
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Analytic validation of an assay to detect androgen receptor splice variant ARv7 protein expression on circulating tumor cells from prostate cancer patients
Presented at AACR 2020
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A direct amplicon-based targeted sequencing assay for mutation analysis of single circulating tumor cells and correlation with circulating tumor DNA
Presented at AACR 2020
This pdf contains an audio narration, after downloading, please enable 3D content in Acrobat to hear the audio
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Sequential same slide multiplex immunofluorescence and H&E staining for combined phenotypic and morphologic characterization of formalin-fixed paraffin-embedded tissue sections
Presented at AACR 2020
This pdf contains an audio narration, after downloading, please enable 3D content in Acrobat to hear the audio
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Introduction of a robust workflow for the whole-side acquisition and co-registration of multiplex immunofluorescence tissue images for analysis of a 9-color, 8-marker immunophenotyping assay
Presented at AACR 2020
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Validation of an assay to detect programmed death-ligand 1 (PD-L1) expression on circulating tumor cells
Presented at TriCon 2020
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Sensitive Detection and Quantification of CAR-T Cells in Treated Patients
Presented by Crown Bio at AACR 2019
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Pick-Seq®: Spatial tissue analysis via multi‑parameter imaging and RNA sequencing of micro‑regions
Presented at SITC 2019
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Multiplex Immunofluorescence Staining, Whole Slide Imaging, and Spatial Phenotyping of T cell Exhaustion, Regulatory T cells, and Myeloid Derived Suppressor Cells in Tumor FFPE Samples
Presented at SITC 2019
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Amplicon-based targeted sequencing of single circulating tumor cells
Presented at AMP 2019
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Custom biomarker investigation of circulating tumor cells using RarePlex® Developer Kits
Presented at ACTC 2019
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Identification, retrieval, and RNA sequencing of single rare antigen-specific T cells from circulation using the RareCyte® platform
Presented at AACR 2019
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Targeted single cell DNA sequencing without prior whole genome amplification for mutational analysis of circulating tumor cells
Presented at AACR 2019
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TCR sequencing from tissue micro-regions and single cells utilizing RareCyte® CytePicker® and Archer® Immunoverse™ technologies
Presented at AACR 2019
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Single cell molecular characterization and PD-L1 expression analysis of model CTC using the RareCyte platform
Presented at TriCon 2019
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Multiparameter tissue section imaging and retrieval of image-defined micro-regions for RNA sequencing using the RareCyte platform
Presented at TriCon 2019
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Simultaneous assessment of PD-L1 and IRF1 expression on breast cancer circulating tumor cells
Presented at AACR 2018
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Increased phenotypic depth for automated visual identification of biomarkers on circulating tumor cells by cocktailing epithelial markers EpCAM and cytokeratin
Presented at AACR 2018
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Development of a multi-parameter immunofluorescence assay for identification of circulating tumor cells with epithelial-mesenchymal phenotype
Presented at AACR 2018
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Development of a multi-parameter immunofluorescence assay for simultaneous detection of androgen receptor and androgen receptor variant 7 in prostate cancer circulating tumor cells
Presented at AACR 2018
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Detection and retrieval of multiple myeloma cells with single cell molecular confirmation from peripheral blood by multi-parameter immunofluorescence, automated scanning and image analysis
Presented at AACR 2018
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Novel multi-parameter assays for investigational phenotyping of circulating tumor cells
Presented at Next Gen Dx 2018
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