Orion^™

Spatial Biology at Scale

Accelerate your protein profiling with the only platform capable of delivering 20 channels per round

Spatial Biology at Scale

Orion dramatically increases the number of biomarkers per round, delivering comprehensive microenvironment profiling at scale, unlocking deeper mechanistic, prognostic, and predictive insights.

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Orion’s plexing power per round accelerates spatial biomarker discovery, seamlessly bridging the gap to translational research.

Protein Spatial Biomarker Discovery

Efficiently profile diverse cell types and states within tissue microenvironments to identify the most clinically relevant biomarkers for downstream validation and clinical impact.

The Orion platform uniquely fulfills every essential requirement for translational spatial biology, empowering high-throughput studies with unmatched multiplexing, robust panel validation, and reliable, large-scale clinical insights.

Read the Harvard study

Spatial Biology for Translational Research

Scaling Spatial Biology for Unmatched Discovery and Translational Impact

High-throughput with a range of plex for discovery and translational studies of any size, all on the same platform.

Stain in batches while imaging in parallel, ensuring rapid turnaround, low per-sample costs, and seamless collaboration for multi-user and high-volume projects.

Benefit from a comprehensive support ecosystem, including expert onboarding and ongoing assistance, to scale up quickly and guarantee your team’s success from day one.

Any Tissue, Any Indication, 20 Channels in a Single Round

Applications that matter to you. Explore our interactive datasets.

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“Every Pathology field has a set of molecular questions that have remained unanswered, and now we have a tool that can start to provide some answers."

Dr. Sandro Santagata, MD, PhD
Associate Director, Laboratory of Systems Pharmacology | Harvard Medical School

Design High-Quality, Customizable Biomarker Panels with Confidence

Orion streamlines panel development with validated antibodies, ready-to-use panels, and labeling kits for custom markers.

RareCyte also offers custom panel design, biomarker conjugation, and validation support tailored to your needs. Stain all proteins in one round to simplify validation, speed development, and ensure high-quality, reproducible data.

View Orion Panels & Antibodies

Orion Workflow: Whole Slide, High-Plex, High-Throughput

Standard pathology workflow enabling batch staining without occupying the scanner to facilitate large volume studies and multi-user environments. Whole slide scanning compatible with large and/or multiple specimens per slide. 20 channels per round for pristine data quality at maximum efficiency.

Orion Workflow

One advantage of Orion is staining 17 antibodies all at once. Compared to the cyclic IF, you don’t have to do stripping which can lead to a loss of antibody antigenicity following antigen degradation and the tissue is not altered, so the detection of the antigen is optimal. In addition, you don't have to design the position of the antibodies in the cycle. This technology saves time.

Yuna Delarue
Laboratory Technician | CHU de Brest

Transforming Spatial Data into Actionable Insights

Orion delivers high quality reproducible data built on foundation of validated reagents and single-round tissue integrity.

Integrated parallel processing streamlines segmentation, feature calculation, and classification, accelerating your pathway to insights.

OME.tiff standard image and CSV data table outputs enable integration into existing analysis workflows.

Orion: Benchtop Imaging Powerhouse. Quantum Leap for Spatial Biology.

Orion’s pioneering design delivers an unprecedented number of markers per round, clearing the pathway for translational spatial biology.

High-powered lasers and narrow band emission filters for 20-channel sensitivity and specificity across a wide spectral range
Sub-micron resolution across entire tissue sections
Brightfield optics for same-section H&E to align morphology to molecular markers
On-board high speed image processing and analysis for rapid and accurate quantitative results
OMERO-based data management system for multi-user environments