Enable whole slide tissue analysis for Research and Clinical Applications

High-plex imaging across an entire slide, in a single scan, enables spatial analysis through examining biomarker expression, cell classification, and subcellular localization. Such analysis paves a path for advancing studies in pathology, immuno-oncology, infectious disease, and many more areas of disease.

Learn more about the Orion^™ Multiplex Imaging Instrument, the critical technology in the Orion platform workflow.

Rapid Tissue Analysis for Any Sample

Lung tissue

CD68 (blue), CD163 (yellow), CD31 (red), ECad (magenta), CK (white). scale bar = 100 μm

Skin tissue (melanoma)

SYTOX (blue), S100 (yellow), Ki67 (red), TIGIT (green). scale bar = 20 μm

Thymus tissue

Vimentin (blue), ECad (magenta), PanCK (green), CAM5.2 (red). scale bar = 200 μm

Tonsil tissue

CD20 (blue), CD4 (white), Ki67 (red), PanCK (yellow). scale bar = 1000 μm

21-plex imaging of lung carcinoma with the Orion Instrument

A single lung section was stained with Orion reagents and imaged using the Orion instrument. All biomarkers were stained in a single round and imaged in a single scan. Three regions of interest (ROIs) are shown below that highlight the channels. Additional single channel images are shown in grayscale for clarity.

Neoplastic Lung

Image above shows cytokeratin-positive, focally TTF1-positive carcinoma in ROI #1. CD8a (magenta), Nuclei (blue), Pan-cytokeratin (green), SMA (white), and TTF1 (red).

Non-neoplastic Lung

Image above shows area of non-neoplastic lung tissue in ROI #2. CD8a (magenta), Nuclei (blue), Pan-cytokeratin (green), and TTF1 (red). 

Lymphoid Aggregate

Lymphoid aggregate is shown above with germinal center in ROI #3. PD-1 (purple), CD8a (magenta), CD3d (red), CD11b (green), and Ki67 (blue).