Orion
Orion Applications

Enable whole slide tissue analysis for Research and Clinical Applications


High-plex imaging across an entire slide, in a single scan, enables spatial analysis through examining biomarker expression, cell classification, and subcellular localization. Such analysis paves a path for advancing studies in pathology, immuno-oncology, infectious disease, and many more areas of disease. Learn more about the Orion Multiplex Imaging Instrument, the critical technology in the Orion platform workflow.



request information




Explore research and clinical applications utilizing the Orion spatial biology platform

Dr Pashtoon Kasi

Nature Oncogene publication: Neoadjuvant botensilimab plus balstilimab response pattern investigated
Dr. Pashtoon Kasi, Weill Cornell Medicine
Read the publication ➝

Dr Zbigniew Mikuluski

Editorial article: Quantitative microscopy for precision spatial biology: “From samples to knowledge”
Dr. Zbigniew Mikulski, La Jolla Institute for Immunology
Read the article ➝

SelectScience

Interview: Bringing spatial biology to the clinic: “A new lens on cancer biology”
Dr. Arutha Kulasinghe, University of Queensland
Read the article ➝

Nature Cancer

Nature Cancer publication and Harvard Tissue Atlas

Read the publication ➝
View the atlas ➝



citations See Orion citations on Google Scholar

Dr Peter Sorger

Webinar: Multimodal tissue imaging and machine learning to advance precision medicine
Dr. Peter K Sorger, Harvard Medical School
Watch the webinar ➝

Dr. Estefania Quesada-Masachs

Webinar: Spatial analysis and high-plex immunofluorescence to study human pancreata in type 1 diabetes
Dr. Estefania Quesada-Masachs, La Jolla Institute for Immunology
Watch the webinar ➝

Dr Sandro Santagata

Webinar: Multiplexed Tissue Imaging using the Orion Platform to Reveal the Spatial Biology of Cancer
Dr. Sandro Santagata, Brigham and Women’s Hospital
Watch the webinar ➝

Dr Pashtoon Kasi

Nature Oncogene publication: Neoadjuvant botensilimab plus balstilimab response pattern investigated
Dr. Pashtoon Kasi, Weill Cornell Medicine
Read the publication ➝
Read the GI Research Foundation’s article ➝



citations See the list of RareCyte publications





Rapid tissue analysis for any sample

Tongue – Oral Squamous Cell Carcinoma

Whole-slide tissue section of an oral squamous cell carcinoma stained with a 16-plex biomarker panel and imaged with the Orion system in a single staining and imaging process.


Oral SCC

Biomarker panel:

  • Nuclear (Hoechst)
  • CD31
  • CD45
  • Vimentin
  • CD4
  • FOXP3
  • CD8a
  • MYH11
  • CD20
  • FAP
  • CD3e
  • E-Cadherin
  • PD-1
  • Ki-67
  • Pan-CK
  • Smooth Muscle Actin
  • View the full interactive data set ➝




    Mouse – Ileum

    Whole-slide tissue section of a mouse ileum stained with a 15-plex biomarker panel.


    Mouse Ileum

    Biomarker panel:

  • Nuclear (Hoechst)
  • KI67
  • Vimentin
  • Pan-CK
  • Beta 2 Microglobulin
  • CD3e
  • Autofluorescence
  • CD8a
  • CD11c
  • CD45R
  • CD163
  • E-Cadherin
  • F4/80
  • FOXP3
  • NaK-ATPase
  • PD-L1
  • View the full interactive data set ➝




    Mouse – Spleen

    Whole-slide tissue section of a mouse spleen stained with a 13-plex biomarker panel.


    Mouse Spleen

    Biomarker panel:

  • Nuclear (Hoechst)
  • Autofluorescence
  • Vimentin
  • CD3e
  • KI67
  • CD45R
  • CD11c
  • Hoechst
  • Beta 2 Microglobulin
  • CD8a
  • CD163
  • F4/80
  • FOXP3
  • Pan-CK
  • PD-L1
  • View the full interactive data set ➝




    Liver

    Whole-slide tissue section of a liver sample stained with a 14-plex biomarker panel.


    liver CRC

    Liver CRC

    Biomarker panel:

  • Nuclear (Hoechst)
  • Autofluorescence
  • Nucleus
  • CD31
  • CD68
  • CD3e
  • Ki-67
  • Albumin
  • Pan-CK
  • FOLR2
  • CD163
  • PD-1
  • PD-L1
  • CD20
  • CD4
  • CD8a
  • View the full interactive data set ➝




    download the brochure