Orion Applications
Enable whole slide tissue analysis for Research and Clinical Applications
High-plex imaging across an entire slide, in a single scan, enables spatial analysis through examining biomarker expression, cell classification, and subcellular localization. Such analysis paves a path for advancing studies in pathology, immuno-oncology, infectious disease, and many more areas of disease. The Orion™ Spatial Biology system continues to be utilized across a multitude of research and clinical applications worldwide. Read below to learn more.
Explore research and clinical applications utilizing the Orion Spatial Imager
Nature Oncogene publication: Neoadjuvant botensilimab plus balstilimab response pattern investigated
Dr. Pashtoon Kasi, Weill Cornell Medicine
Read the publication ➝
Read the GI Research Foundation's article ➝
Editorial article: Quantitative microscopy for precision spatial biology: “From samples to knowledge”
Dr. Zbigniew Mikulski, La Jolla Institute for Immunology
Read the article ➝
Webinar: Use of open-source software for quantitative analysis of multiplex images
Presented by Dr. Sara McArdle, La Jolla Institute of Immunology
Watch the webinar ➝
Webinar: Multimodal tissue imaging and machine learning to advance precision medicine
Dr. Peter K Sorger, Harvard Medical School
Watch the webinar ➝
Webinar: Spatial analysis and high-plex immunofluorescence to study human pancreata in type 1 diabetes
Dr. Estefania Quesada-Masachs, La Jolla Institute for Immunology
Watch the webinar ➝
Webinar: Multiplexed Tissue Imaging using the Orion Platform to Reveal the Spatial Biology of Cancer
Dr. Sandro Santagata, Brigham and Women’s Hospital
Watch the webinar ➝
See Orion citations on Google Scholar
See the list of RareCyte publications
Rapid tissue analysis for any sample
Tongue – Oral Squamous Cell Carcinoma
Whole-slide tissue section of an oral squamous cell carcinoma stained with a 16-plex biomarker panel and imaged with the Orion Spatial Imager in a single staining and imaging process.
Biomarker panel:
- Nuclear (Hoechst)
- CD31
- CD45
- Vimentin
- CD4
- FOXP3
- CD8a
- MYH11
- CD20
- FAP
- CD3e
- E-Cadherin
- PD-1
- Ki-67
- Pan-CK
- Smooth Muscle Actin
Mouse – Ileum
Whole-slide tissue section of a mouse ileum stained with a 15-plex biomarker panel.
Biomarker panel:
- Nuclear (Hoechst)
- KI67
- Vimentin
- Pan-CK
- Beta 2 Microglobulin
- CD3e
- Autofluorescence
- CD8a
- CD11c
- CD45R
- CD163
- E-Cadherin
- F4/80
- FOXP3
- NaK-ATPase
- PD-L1
Mouse – Spleen
Whole-slide tissue section of a mouse spleen stained with a 13-plex biomarker panel.
Biomarker panel:
- Nuclear (Hoechst)
- Autofluorescence
- Vimentin
- CD3e
- KI67
- CD45R
- CD11c
- Beta 2 Microglobulin
- CD8a
- CD163
- F4/80
- FOXP3
- Pan-CK
- PD-L1
Liver
Whole-slide tissue section of a liver stained with a 14-plex biomarker panel.
Biomarker panel:
- Nuclear (Hoechst)
- Autofluorescence
- CD31
- CD68
- CD3e
- Ki-67
- Albumin
- Pan-CK
- FOLR2
- CD163
- PD-1
- PD-L1
- CD20
- CD4
- CD8a