Featured Publication

Circulating tumor cell detection: A prospective comparison between CellSearch® and RareCyte® platforms in patients with progressive metastatic breast cancer

Circulating tumor cells (CTCs) are prognostic in patients with breast cancer. Several technical platforms exist for their enumeration and characterization. Comparative studies between these platforms are scarce. The RareCyte CTC detection is theoretically more sensitive than the established CellSearch platform, which identifies only CTCs that express EpCAM and cytokeratin. This study prospectively compares CTC enumeration in patients with breast cancer in a paired analysis using these two platforms. It investigates survival outcomes in groups defined by a CTC count threshold.

Dirix L, Buys A, Oeyen S. et al.
Breast Cancer Res Treat. 2022.
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Select Publications

Non-Invasive Profiling of Advanced Prostate Cancer via Multi-Parametric Liquid Biopsy and Radiomic Analysis
Morrison G, Buckley J, Ostrow D, et al.
Molecular Sciences. 2022; 23(5):2571.
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Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer
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Nat Commun. 2022;13(835).
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Front. Pharmacol. 2022: 13:835727.
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Barbirou M, Miller A, Manjunath Y, et al.
Current Issues in Molecular Biology. 2022; 44(2):750-763.
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Heterogeneity of Circulating Tumor Cell Neoplastic Subpopulations Outlined by Single-Cell Transcriptomics
Pauken CM, Kenney SR, Brayer KJ, et al.
Cancers. 2021; 13(19), 4885.
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Identification and Characterization of Effusion Tumor Cells (ETCs) From Remnant Pleural Effusion Specimens
Zhu Y, Allard GM, Ericson NG, George TC, Kunder CA, Lowe AC.
Cancer Cytopathol. 2021;129(11):893-906.
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A single-cell landscape of high-grade serous ovarian cancer
Izar B, Tirosh I, Stover EH, et al.
Nat Med. 2020;26(8):1271-1279.
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SARS-CoV-2 infection protects against rechallenge in rhesus macaques
Chandrashekar A, Liu J, Martinot AJ, et al.
Science. 2020;369(6505):812-817.
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Circulating tumor cell investigation in breast cancer patient-derived xenograft models by automated immunofluorescence staining, image acquisition, and single cell retrieval and analysis
Ramirez AB, Bhat R, Sahay D, et al.
BMC Cancer. 2019;19(220).
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PIC&RUN: An integrated assay for the detection and retrieval of single viable circulating tumor cells
Kamal M, Saremi S, Klotz R, et al.
Sci Rep. 2019;9(17470).
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Validation Studies for Single Circulating Trophoblast Genetic Testing as a Form of Noninvasive Prenatal Diagnosis
Vossaert L, Wang Q, Salman R, et al.
American Journal of Human Genetics. 2019;105:1-12
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A Rapid Method for Label-Free Enrichment of Rare Trophoblast Cells from Cervical Samples
Bailey-Hytholt C, Sayeed S, Kraus M, et al.
SciRep. 2019;9(12115).
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A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade
L Jerby-Arnon, P Shah, M Cuoco, et al.
Cell. 2018; 175(4): 984-997.
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The RareCyte® Platform for Next-Generation Analysis of Circulating Tumor Cells
Kaldjian E, Ramirez A, Sun Y, et al.
Cytometry Part A. 2018;93A:1220-1225.
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Reliable detection of subchromosomal deletions and duplications using cell-based noninvasive prenatal testing
Vossaert L, Wang Q, Salman R, et al.
Prenat Diagn. 2018;38(13):1069-1078.
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Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes
Lin JR, Izar B, Wang S, et al.
Elife. 2018;7:e31657. Published 2018 Jul 11.
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Prostate cancer disseminated tumor cells are rarely detected in the bone marrow of patients with localized disease undergoing radical prostatectomy across multiple rare cell detection platforms
Chalfin HJ, Glavaris SA, Malihi PD, et al.
J Urol. 2018;199(6):1494-1501.
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A distributed network for intensive longitudinal monitoring in metastatic triple-negative breast cancer
Blau CA, Ramirez AB, Blau S, et al.
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Evidence for feasibility of fetal trophoblastic cell-based noninvasive prenatal testing
Breman AM, Chow JC, U’Ren L, et al.
Prenat Diagn. 2016;36(11):1009-1019.
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High-recovery visual identification and single-cell retrieval of circulating tumor cells for genomic analysis using a dual-technology platform integrated with automated immunofluorescence staining
Campton DE, Ramirez AB, Nordberg JJ, et al.
BMC Cancer. 2015;15:360. Published 2015 May 6.
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