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Accurate isolation and detection of circulating tumor cells using enrichment-free multiparametric high resolution imaging

The reliable and accurate detection of rare circulating tumor cells (CTCs) from cancer patient blood samples promises advantages in both research and clinical applications. Numerous CTC detection methods have been explored that rely on either the physical properties of CTCs such as density, size, charge, and/or their antigen expression profiles. Multiple factors can influence CTC recovery including blood processing method and time to processing.

Yeo D, Kao S, Gupta R, et al.
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Multi-modal digital pathology for colorectal cancer diagnosis by high-plex immunofluorescence imaging and traditional histology of the same tissue section
Lin J, Chen Y, Campton D, et al.
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Metastasis from the tumor interior and necrotic core formation are regulated by breast cancer-derived angiopoietin-like 7
Yamamoto A, Huang Y, Krajina B, et al.
PNAS 2023 Vol. 120 No. 10
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Circulating tumor cell detection: A prospective comparison between CellSearch^® and RareCyte^® platforms in patients with progressive metastatic breast cancer
Dirix L, Buys A, Oeyen S, et al.
Breast Cancer Res Treat. 2022.
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Clinical validation of a circulating tumor cell assay using density centrifugation and automated immunofluorescence microscopy
Sabath D, Perrone M, Clein A, et al.
Am J Clin Pathol 2022, 158(02):1-7
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Safety, Feasibility, and Merits of Longitudinal Molecular Testing of Multiple Metastatic Sites to Inform mTNBC Patient Treatment in the Intensive Trial of Omics in Cancer
Burton K, Mahen E, Konnick E, et al.
JCO Precis Oncol 6:e2100280.
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Liquid Biopsy Assessment of Circulating Tumor Cell PD‑L1 and IRF‑1 Expression in Patients with Advanced Solid Tumors Receiving Immune Checkpoint Inhibitor
Kennedy L, Lu J, Kuehn S, et al.
Targeted Oncology 2022, 17, 329–341.
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Non-Invasive Profiling of Advanced Prostate Cancer via Multi-Parametric Liquid Biopsy and Radiomic Analysis
Morrison G, Buckley J, Ostrow D, et al.
Molecular Sciences. 2022; 23(5):2571.
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Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer
Launonen IM, Lyytikäinen N, Casado J, et al.
Nat Commun. 2022;13(835).
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Beyond Circulating Tumor Cell Enumeration: Cell-Based Liquid Biopsy to Assess Protein Biomarkers and Cancer Genomics Using the RareCyte^® Platform
Kaldjian EP, Ramirez AB, Costandy L, et al.
Front. Pharmacol. 2022: 13:835727.
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Single Circulating-Tumor-Cell-Targeted Sequencing to Identify Somatic Variants in Liquid Biopsies in Non-Small-Cell Lung Cancer Patients
Barbirou M, Miller A, Manjunath Y, et al.
Current Issues in Molecular Biology. 2022; 44(2):750-763.
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Heterogeneity of Circulating Tumor Cell Neoplastic Subpopulations Outlined by Single-Cell Transcriptomics
Pauken CM, Kenney SR, Brayer KJ, et al.
Cancers. 2021; 13(19), 4885.
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Identification and Characterization of Effusion Tumor Cells (ETCs) From Remnant Pleural Effusion Specimens
Zhu Y, Allard GM, Ericson NG, George TC, Kunder CA, Lowe AC.
Cancer Cytopathol. 2021;129(11):893-906.
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A single-cell landscape of high-grade serous ovarian cancer
Izar B, Tirosh I, Stover EH, et al.
Nat Med. 2020;26(8):1271-1279.
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SARS-CoV-2 infection protects against rechallenge in rhesus macaques
Chandrashekar A, Liu J, Martinot AJ, et al.
Science. 2020;369(6505):812-817.
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Circulating tumor cell investigation in breast cancer patient-derived xenograft models by automated immunofluorescence staining, image acquisition, and single cell retrieval and analysis
Ramirez AB, Bhat R, Sahay D, et al.
BMC Cancer. 2019;19(220).
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PIC&RUN: An integrated assay for the detection and retrieval of single viable circulating tumor cells
Kamal M, Saremi S, Klotz R, et al.
Sci Rep. 2019;9(17470).
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Validation Studies for Single Circulating Trophoblast Genetic Testing as a Form of Noninvasive Prenatal Diagnosis
Vossaert L, Wang Q, Salman R, et al.
American Journal of Human Genetics. 2019;105:1-12
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A Rapid Method for Label-Free Enrichment of Rare Trophoblast Cells from Cervical Samples
Bailey-Hytholt C, Sayeed S, Kraus M, et al.
SciRep. 2019;9(12115).
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A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade
L Jerby-Arnon, P Shah, M Cuoco, et al.
Cell. 2018; 175(4): 984-997.
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The RareCyte^® Platform for Next-Generation Analysis of Circulating Tumor Cells
Kaldjian E, Ramirez A, Sun Y, et al.
Cytometry Part A. 2018;93A:1220-1225.
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Reliable detection of subchromosomal deletions and duplications using cell-based noninvasive prenatal testing
Vossaert L, Wang Q, Salman R, et al.
Prenat Diagn. 2018;38(13):1069-1078.
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Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes
Lin JR, Izar B, Wang S, et al.
Elife. 2018;7:e31657. Published 2018 Jul 11.
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Prostate cancer disseminated tumor cells are rarely detected in the bone marrow of patients with localized disease undergoing radical prostatectomy across multiple rare cell detection platforms
Chalfin HJ, Glavaris SA, Malihi PD, et al.
J Urol. 2018;199(6):1494-1501.
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A distributed network for intensive longitudinal monitoring in metastatic triple-negative breast cancer
Blau CA, Ramirez AB, Blau S, et al.
J Natl Compr Canc Netw. 2016;14(1):8-17.
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Evidence for feasibility of fetal trophoblastic cell-based noninvasive prenatal testing
Breman AM, Chow JC, U’Ren L, et al.
Prenat Diagn. 2016;36(11):1009-1019.
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High-recovery visual identification and single-cell retrieval of circulating tumor cells for genomic analysis using a dual-technology platform integrated with automated immunofluorescence staining
Campton DE, Ramirez AB, Nordberg JJ, et al.
BMC Cancer. 2015;15:360. Published 2015 May 6.
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