Applications
Cell-Based Non-Invasive Prenatal Testing

Non-invasive prenatal testing (NIPT) with gentle single cell isolation


Analyze rare circulating fetal cells (CFCs) from blood for non-invasive prenatal testing

Circulating fetal cells (CFCs) can be isolated from maternal blood and fetal aneuploidies, where number variants can be evaluated by genetic analysis for research purposes.


The RareCyte platform enables CFC analysis, including:

  • Enumeration of CFCs in maternal blood
  • Retrieval of individual CFCs for molecular analysis 
  • Retrieval of individual CRCs for next generation sequencing

Fetal Testing that is Uniquely RareCyte

Analysis of extremely rare CFCs from blood requires a method that is sensitive, specific, and reproducible, and provides the depth of information you need.

The RareCyte platform provides all of the above:

  • Sensitivity: Unbiased and highly sensitive target-cell recovery with the AccuCyte® Sample Preparation System
  • Specificity: Capture and staining antibodies for isolation and detection of fetal cells, and visual confirmation protects against false positives
  • Retrieval: Gentle, single cell isolation for detection of sub-chromosomal duplications and deletions


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An integrated workflow enables fast and easy to follow steps from sample preparation to single-cell retrieval.

Step 1: PREP

Collect nucleated cells from blood and magnetically enrich for CFCs with the CFC Kit and using a simple and reproducible system that transfers nucleated cells from whole blood to slides with minimal target-cell loss.

Step 2: STAIN

Perform immunofluorescence staining with the CFC Kit and pipette onto Chamber slide, using the highly validated circulating tumor cell assay designed to work with the AccuCyte® Sample Preparation System, automated slide staining systems, and CyteFinder® Imaging Instruments.

Step 3: IMAGE

Identify, enumerate, and phenotype through multiparameter imaging with a CyteFinder® Imaging Instrument; a high speed, multi-channel system optimized for rare-cell detection and analysis utilized with the cell option.

Step 4: RETRIEVE

Retrieve single CFCs for molecular analysis with the CytePicker® Retrieval Module, enabling single cell retrieval from any location on the slide.


40x CFC images with CFC-specific biomarkers shown in green and red
Representative 40x CFC images with CFC-specific biomarkers shown in green and red.