Introducing Orion™ HT
The New Standard for Spatial Biomarker Development in Translational and Clinical Research
Orion HT brings continuous 24/7 automation to RareCyte's patented single-round approach, delivering the plex, throughput, and data quality required to translate spatial insights into clinical impact.
Resolve tissue microenvironments at scale
Historically, spatial platforms have forced a tradeoff between plex and throughput. Orion’s ground-breaking 20 channels-per-round design eliminates this compromise. Resolve tissue microenvironments across whole slides for large cohorts, turning phenotypic, structural, and functional biomarkers into validated therapeutic insights.
High-capacity walkaway automation for efficient workflows
Designed for large-scale studies and multi-user environments, Orion HT combines 30-slide automation with continuous scanning to enable sustained, walkaway operation. Automated quantitative analysis is performed in parallel to imaging, accelerating time-to-data so you keep pace with your high-volume workflows.
“We are excited to offer multiplex immunofluorescence for clinical trial biomarker testing leveraging the powerful Orion HT technology. As pioneers in multiplex immunofluorescence for clinical trials, this technology will enable us to efficiently run 18-plex assays in a regulated setting."
Jennifer Bordeaux, PhD
Associate Director, Digital Pathology Solutions | Navigate Biopharma Solutions, Inc.
Learn how Navigate Biopharma validated a 17-plex panel for clinical trials ➝
Quantitative data you can trust
Orion’s single-round workflow avoids iterative stripping and re-probing cycles, preserving tissue integrity and antigen fidelity. Combined with high sensitivity reagents and instrumentation, the platform delivers accurate and reproducible quantitative results.
Rapid and flexible panel development
Build panels from an extensive portfolio of Orion-validated antibody conjugates in fully customizable combinations, with the ability to incorporate your own custom reagents. Orion’s single-round cocktail staining eliminates staining order complexity, accelerating development of reliable, validation-ready panels.
Learn more ➝
Maximize insights from a single tissue section
Clinical samples are precious. Orion detects 20 channels in one round, eliminating the need for serial sections. Plus, its workflow is non-destructive, letting you run future studies on the same slides.
Orion HT Instrument
Best for high-capacity environments running multiple concurrent programs and large clinical studies.
- 20-channel high-speed imaging for biomarker depth at high throughput
- 30-slide capacity for walkaway automation
- Barcode-driven workflow to ensure sample chain of custody
- Real-time quantitative data analysis accelerates time-to-results
- Continuous access to add and remove slides for 24/7 scanning
Which Orion is right for you?
Three models. One platform. Your scale.
Research Spotlight
Webinar: Spatial Biomarker Panels for Clinical Trials
Jennifer Bordeaux, PhD Associate Director, Digital Pathology Solutions Navigate Biopharma Solutions, Inc.
Neoadjuvant botensilimab plus balstilimab response pattern in locally advanced mismatch repair proficient colorectal cancer
Pashtoon Murtaza Kasi, PhD
Weill Cornell Medicine