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Neoadjuvant botensilimab plus balstilimab response pattern in locally advanced mismatch repair proficient colorectal cancer

Significant tumor-shrinking activity was observed following neoadjuvant immunotherapy with botensilimab plus balstilimab (BOT/BAL) in microsatellite stable colorectal cancer (MSS CRC). Whole-slide pre-treatment biopsy and post-treatment surgically resected samples were interrogated using one-step, 13-plex imaging on the Orion spatial biology platform. Quantitative analysis was employed to measure immune cell density and proliferation index within and near the tumor for pre-treatment and post-treatment samples. Spatial biology analysis of patient samples can inform mechanisms of action, providing insight for clinical trial designs using neoadjuvant immunotherapy.

Kasi P, Hidalgo M, Jafari M, et al.
Nature Oncogene 2023
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Classification :

Year	Platform	Biopsy type	Classification	Indication	Journal	Title
2026	CyteFinder	Tissue	Oncology	Ovarian Cancer	Cancer Immunology Research	Ex Vivo Immuno-Oncology Platform Reveals Spatial T Cell Infiltration Patterns Linked to ATR Inhibition Responses in High-Grade Serous Ovarian Cancer
2026	CyteFinder	Liquid Biopsy	Oncology	Breast Cancer	Cancer Research Communications	Surface Marker Identification to Capture Live Circulating Tumor Cells in Metastatic Triple-Negative Breast Cancer
2026	CyteFinder	Liquid Biopsy	Oncology	Head and Neck Cancer	European Journal of Surgical Oncology	Circulating tumor cells predict relapse in head and neck mucosal squamous cell carcinoma
2026	Orion	Tissue	Immunology	Transplant	Nature Medicine	Immune profiling in a living human recipient of a gene-edited pig kidney
2025	Orion	Tissue	Oncology	Glioma	Neuro-Oncology	P08.12.B NAVIG-1: A PHASE I/IIA STUDY EVALUATING AN ANTI-TELOMERASE IMMUNOTHERAPY IN GLIOBLASTOMA
2025	Orion	Tissue	Oncology	Colorectal Cancer	arXiv	Virtual Multiplex Staining for Histological Images using a Marker-wise Conditioned Diffusion Model
2025	Orion	Tissue	Oncology	Colorectal Cancer	arXiv	Cross-Domain Image Synthesis: Generating H&E from Multiplex Biomarker Imaging
2025	Orion	Tissue	Oncology	Leukemia	Nature Communications	Integrative multi-omics reveals a regulatory and exhausted T-cell landscape in CLL and identifies galectin-9 as an immunotherapy target
2025	CyteFinder	Liquid Biopsy	Oncology	Breast Cancer	Preprint	Comprehensive Longitudinal Linear Mixed Modelling of CTCs Illuminates the Role of Trop2, EpCAM, and CD45 in CTC Clustering and Metastasis
2025	CyteFinder	Tissue, TMA	Oncology	Breast Cancer	JCO Precision Oncology	Quantitative Multiplex Immunofluorescence Assay for Trophoblast Cell-Surface Antigen 2 and Human Epidermal Growth Factor Receptor 2 Expression in Breast Cancer: Toward Guiding Patient Selection for Antibody-Drug Conjugate Therapies
2025	CyteFinder	Tissue	Oncology	Breast Cancer	Breast Cancer Research Treatment	Quantitative assessment of HER2 expression in invasive ductal carcinoma and co-existing DCIS
2025	CyteFinder	Liquid Biopsy	Oncology		BioTechniques	A novel device for buffy coat collection
2025	CyteFinder	Tissue	Oncology	Brain Cancer	Clinical Cancer Research	Pre-clinical Modeling of Navtemadlin Pharmacokinetics, Pharmacodynamics, and Efficacy in IDH-wildtype Glioblastoma
2025	CyteFinder	Tissue	Immunology		JCI Insight	Resident memory T cell development is gradual and shows AP-1 gene expression in mature cells
2024	Orion	Tissue	Immunology	Thymus	Nature	A spatial human thymus cell atlas mapped to a continuous tissue axis
2025	Orion	Tissue	Oncology	Pancreatic Cancer	BioRxiv	Spatial Biology and Organoid Technologies Reveal a Potential Therapy-Resistant Cancer Stem Cell Population in Pancreatic Ductal Adenocarcinoma
2025	CyteFinder	Tissue	Oncology	Breast cancer	medRxiv	Validation and Prospective Testing of a High Sensitivity, Quantitative Analytic Assay for HER2 on Histopathology Slides
2025	Orion	Tissue			arXiv	MIPHEI-ViT: Multiplex Immunofluorescence Prediction from H&E Images using ViT Foundation Models
2025	CyteFinder	Tissue	Oncology	Breast cancer	JCI Insight	Imlunestrant a next-generation oral SERD overcomes ESR1 mutant resistance in estrogen receptorpositive breast cancer
2025	CyteFinder	Liquid Biopsy	Oncology	Pancreatic Cancer	Cellular and Molecular Life Sciences	Portal venous circulating tumor cells as a biomarker for relapse prediction in resected pancreatic cancer
2025	Orion	Tissue	Immunology		Nature Immunology	ImmGenMaps, an open-source cartography of the immune system
2025	CyteFinder	Tissue	Infectious Disease	TB	BioRxiv	Multiomic analysis identifies suppressive myeloid cell populations in human TB granulomas
2025	CyteFinder	Tissue, TMA	Oncology	Lung Cancer	Clinical Cancer Research	Quantitative Protein Expression of Antibody-Drug Conjugate Targets in EGFR Mutated and Wild-Type Non-Small Cell Lung Cancer
2025	CyteFinder	Liquid Biopsy	Oncology	Brain Cancer	Nature Medicine	Neoadjuvant triplet immune checkpoint blockade in newly diagnosed glioblastoma
2025	CyteFinder	Tissue	Oncology	Brain Cancer	BioRxiv	A pathogenic subpopulation of human glioma associated macrophages linked to glioma progression
2025	Orion	Tissue, TMA	Oncology	Breast Cancer	BioRxiv	Swirling motion of breast cancer cells radially aligns collagen fibers to enable collective invasion
2025	Orion	Tissue	Immuno-oncology		BioRxiv	Macrophages restrict tumor permissiveness to immune infiltration by controlling local collagen topography through a Tcf4-Collagen3 fibrotic axis
2024	Orion	Tissue	Oncology	Lymphoma	Nature Immunology	Cutaneous T cell lymphoma atlas reveals malignant TH2 cells supported by a B cell-rich tumor microenvironment
2024	CyteFinder	Tissue	Oncology	Ovarian Cancer	Cancer Discovery	Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma
2024	CyteFinder	Tissue	Oncology	Ovarian Cancer	Cancer Cell	Chemotherapy induces myeloid-driven spatially confined T cell exhaustion in ovarian cancer
2024	CyteFinder	Tissue	Oncology	Ovarian Cancer	Cell	Ovarian cancer-derived IL-4 promotes immunotherapy resistance
2024	CyteFinder	Tissue	Oncology	Breast Cancer	NPJ Breast Cancer	Pure estrogen receptor antagonists potentiate capecitabine activity in ESR1-mutant breast cancer
2024	Orion	Tissue	Digital Pathology		Medical Image Analysis	Immunocto: a massive immune cell database auto-generated for histopathology
2024	Orion	Tissue	Immuno-oncology	Chronic Lymphocytic Leukemia	Nature Portfolio	Integrative multi-omics identifies regulatory and exhausted T cell types and novel immunotherapy targets in CLL lymph nodes
2024	CyteFinder	Tissue	Oncology	Breast Cancer	Nature Communications	Reciprocal antagonism of PIN1-APC/CCDH1 governs mitotic protein stability and cell cycle entry
2024	CyteFinder	Liquid Biopsy	NIPT	NIPT	Prenatal Diagnosis	Noninvasive single‐cell‐based prenatal genetic testing: A proof of concept clinical study
2024	Orion	Tissue	Aging		Nature Aging	Human skeletal muscle aging atlas
2024	CyteFinder	Tissue	Oncology	Breast Cancer	NPJ Breast Cancer	Qualification of a multiplexed tissue imaging assay and detection of novel patterns of HER2 heterogeneity in breast cancer
2024	CyteFinder	Liquid Biopsy	Oncology		Cancer Cytopatholoty	Detection of effusion tumor cells under different storage and processing conditions
2024	CyteFinder	Tissue	Oncology	Liposarcoma	Clinical Cancer Research	Phase II Study of Eribulin plus Pembrolizumab in Metastatic Soft Tissue Sarcomas: Clinical Outcomes and Biological Correlates.
2023	CyteFinder	Tissue	Immuno-oncology	Breast Cancer	Frontiers in Immunology	Antigen presentation deficiency, mesenchymal differentiation, and resistance to immunotherapy in the murine syngeneic CT2A tumor model
2023	CyteFinder	Liquid Biopsy	Oncology	Colorectal Cancer	Frontiers in Oncology	Circulating tumor cell enumeration, biomarker analyses, and kinetics in patients with colorectal cancer and other GI malignancies
2023	CyteFinder	Liquid Biopsy	Oncology	Colorectal Cancer	The Journal of Liquid Biopsy	Liquid biopsy kinetics and detection of ERBB2 amplification/HER2-positivity in refractory hepatocellular carcinoma
2023	Orion	Tissue	Oncology	Chronic Lymphocytic Leukemia	BioRxiv	High-dimensional single-cell definition of CLL T cells identifies Galectin-9 as novel immunotherapy target
2023	Orion	Tissue	Oncology	Colorectal Cancer	Nature Oncogene	Neoadjuvant botensilimab plus balstilimab response pattern in locally advanced mismatch repair proficient colorectal cancer
2023	Orion	Tissue	Oncology	Colorectal Cancer	Nature Cancer	High-plex immunofluorescence imaging and traditional histology of the same tissue section for discovering image-based biomarkers
2023	CyteFinder	Liquid Biopsy	Oncology	Breast Cancer	PNAS	Metastasis from the tumor interior and necrotic core formation are regulated by breast cancer-derived angiopoietin-like 7
2023	CyteFinder	Tissue	Oncology	Colorectal Cancer	Cell	Multiplexed 3D atlas of state transitions and immune interaction in colorectal cancer
2023	CyteFinder	Liquid Biopsy	Oncology		Frontiers in Oncology	Accurate isolation and detection of circulating tumor cells using enrichment-free multiparametric high resolution imaging
2022	CyteFinder	Liquid Biopsy	Oncology	Breast Cancer	Breast Cancer Research and Treatment	Circulating tumor cell detection: a prospective comparison between CellSearch and Rarecyte platforms in patients with progressive metastatic breast cancer.
2022	CyteFinder	Tissue	Oncology	Ovarian Cancer	Nature	Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer
2022	CyteFinder	Liquid Biopsy	Oncology		American Journal of Clinical Pathology	Clinical validation of a circulating tumor cell assay using density centrifugation and automated immunofluorescence microscopy
2022	CyteFinder	Tissue	Oncology	Melanoma	Cancer Discovery	The Spatial Landscape of Progression and Immunoediting in Primary Melanoma at Single-Cell Resolution
2022	CyteFinder	Liquid Biopsy	Oncology		Frontiers	Beyond circulating tumor cell enumeration: cell-based liquid biopsy to asses protein biomarkers and cancer genomics
2022	CyteFinder	Liquid Biopsy	Immuno-oncology	Prostate Cancer	International Journal of Molecular Sciences	Non-Invasive Profiling of Advanced Prostate Cancer via Multi-Parametric Liquid Biopsy and Radiomic Analysis
2022	CyteFinder	Liquid Biopsy	Oncology	NSCLC	Current issues in Molecular biology	Single Circulating-Tumor-Cell-Targeted Sequencing to Identify Somatic Variants in Liquid Biopsies in Non-Small-Cell Lung Cancer Patients
2021	CyteFinder	Liquid Biopsy	Oncology	Breast cancer	Cancers	Heterogeneity of Circulating Tumor Cell Neoplastic Subpopulations Outlined by Single-Cell Transcriptomics
2021	CyteFinder	Tissue	Oncology	GI cancer	Clinical Cancer Research	HAND1 and BARX1 Act as Transcriptional and Anatomic Determinants of Malignancy in Gastrointestinal Stromal Tumor
2021	CyteFinder	Liquid Biopsy	Oncology	NSCLC	Clinical Chemistry	Proficiency Testing to Assess Technical Performance for CTC-Processing and Detection Methods in CANCER-ID
2021	CyteFinder	Liquid Biopsy	Oncology	Breast Cancer	Molecular Cancer Research	N-Acetyl-L-cysteine Promotes Ex Vivo Growth and Expansion of Single Circulating Tumor Cells by Mitigating Cellular Stress Responses
2021	CyteFinder	Tissue	Immuno-oncology	Skin Cancer	Nat Medicine	Evolution of delayed resistance to immunotherapy in a melanoma responder
2021	CyteFinder	Liquid Biopsy	Oncology		Cancer Cytopathology	Identification and Characterization of Effusion Tumor Cells (ETCs) From Remnant Pleural Effusion Specimens
2020	CyteFinder	Tissue	Infectious disease	COVID-19	Science	SARS-CoV-2 infection protects against rechallenge in rhesus macaques
2020	CyteFinder	Tissue	Oncology	Ovarian Cancer	Nature Medicine	A single-cell landscape of high-grade serous ovarian cancer
2019	CyteFinder	Liquid Biopsy	NIPT	Cervical Cancer	Scientific Reports	A Rapid Method for Label-Free Enrichment of Rare Trophoblast Cells from Cervical Samples
2019	CyteFinder	Tissue	Immuno-oncology		Nature Protocol	Qualifying antibodies for image-based immune profiling and multiplexed tissue imaging
2019	CyteFinder	Liquid Biopsy	Oncology	Breast Cancer	Scientific Reports	PIC&RUN: An integrated assay for the detection and retrieval of single viable circulating tumor cells
2019	CyteFinder	Liquid Biopsy	Oncology	Breast Cancer	BMC Cancer	Circulating tumor cell investigation in breast cancer patient-derived xenograft models by automated immunofluorescence staining, image acquisition, and single cell retrieval and analysis
2018	CyteFinder	Liquid Biopsy	Oncology	Prostate Cancer	The Journal of Urology	Prostate Cancer Disseminated Tumor Cells are Rarely Detected in the Bone Marrow of Localized Patients Undergoing Radical Prostatectomy Across Multiple Rare Cell Detection Platforms
2018	CyteFinder	Tissue	Immuno-oncology		eLife	Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes
2018	CyteFinder	Tissue	Immuno-oncology	Skin Cancer	Cell	A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade
2018	CyteFinder	Liquid Biopsy	NIPT	NIPT	Prenatal Diagnosis	Reliable detection of subchromosomal deletions and duplications using cell‐based noninvasive prenatal testing
2016	CyteFinder	Liquid Biopsy	Oncology	Breast cancer	J. National Comprehensive Cancer Network	A Distributed Network for Intensive Longitudinal Monitoring in Metastatic Triple-Negative Breast Cancer
2016	CyteFinder	Liquid Biopsy	NIPT	NIPT	Prenatal Diagnosis	Evidence for feasibility of fetal trophoblastic cell-based noninvasive prenatal testing
2015	CyteFinder	Liquid Biopsy	Oncology		BMC Cancer	High-recovery visual identification and single-cell retrieval of circulating tumor cells for genomic analysis using a dual-technology platform integrated with automated immunofluorescence staining
	Platform		Classification

Platform :

Classification :

Year	Platform	Biopsy type	Classification	Indication	Journal	Title
2026	CyteFinder	Tissue	Oncology	Ovarian Cancer	Cancer Immunology Research	Ex Vivo Immuno-Oncology Platform Reveals Spatial T Cell Infiltration Patterns Linked to ATR Inhibition Responses in High-Grade Serous Ovarian Cancer
2026	CyteFinder	Liquid Biopsy	Oncology	Breast Cancer	Cancer Research Communications	Surface Marker Identification to Capture Live Circulating Tumor Cells in Metastatic Triple-Negative Breast Cancer
2026	CyteFinder	Liquid Biopsy	Oncology	Head and Neck Cancer	European Journal of Surgical Oncology	Circulating tumor cells predict relapse in head and neck mucosal squamous cell carcinoma
2026	Orion	Tissue	Immunology	Transplant	Nature Medicine	Immune profiling in a living human recipient of a gene-edited pig kidney
2025	Orion	Tissue	Oncology	Glioma	Neuro-Oncology	P08.12.B NAVIG-1: A PHASE I/IIA STUDY EVALUATING AN ANTI-TELOMERASE IMMUNOTHERAPY IN GLIOBLASTOMA
2025	Orion	Tissue	Oncology	Colorectal Cancer	arXiv	Virtual Multiplex Staining for Histological Images using a Marker-wise Conditioned Diffusion Model
2025	Orion	Tissue	Oncology	Colorectal Cancer	arXiv	Cross-Domain Image Synthesis: Generating H&E from Multiplex Biomarker Imaging
2025	Orion	Tissue	Oncology	Leukemia	Nature Communications	Integrative multi-omics reveals a regulatory and exhausted T-cell landscape in CLL and identifies galectin-9 as an immunotherapy target
2025	CyteFinder	Liquid Biopsy	Oncology	Breast Cancer	Preprint	Comprehensive Longitudinal Linear Mixed Modelling of CTCs Illuminates the Role of Trop2, EpCAM, and CD45 in CTC Clustering and Metastasis
2025	CyteFinder	Tissue, TMA	Oncology	Breast Cancer	JCO Precision Oncology	Quantitative Multiplex Immunofluorescence Assay for Trophoblast Cell-Surface Antigen 2 and Human Epidermal Growth Factor Receptor 2 Expression in Breast Cancer: Toward Guiding Patient Selection for Antibody-Drug Conjugate Therapies
2025	CyteFinder	Tissue	Oncology	Breast Cancer	Breast Cancer Research Treatment	Quantitative assessment of HER2 expression in invasive ductal carcinoma and co-existing DCIS
2025	CyteFinder	Liquid Biopsy	Oncology		BioTechniques	A novel device for buffy coat collection
2025	CyteFinder	Tissue	Oncology	Brain Cancer	Clinical Cancer Research	Pre-clinical Modeling of Navtemadlin Pharmacokinetics, Pharmacodynamics, and Efficacy in IDH-wildtype Glioblastoma
2025	CyteFinder	Tissue	Immunology		JCI Insight	Resident memory T cell development is gradual and shows AP-1 gene expression in mature cells
2024	Orion	Tissue	Immunology	Thymus	Nature	A spatial human thymus cell atlas mapped to a continuous tissue axis
2025	Orion	Tissue	Oncology	Pancreatic Cancer	BioRxiv	Spatial Biology and Organoid Technologies Reveal a Potential Therapy-Resistant Cancer Stem Cell Population in Pancreatic Ductal Adenocarcinoma
2025	CyteFinder	Tissue	Oncology	Breast cancer	medRxiv	Validation and Prospective Testing of a High Sensitivity, Quantitative Analytic Assay for HER2 on Histopathology Slides
2025	Orion	Tissue			arXiv	MIPHEI-ViT: Multiplex Immunofluorescence Prediction from H&E Images using ViT Foundation Models
2025	CyteFinder	Tissue	Oncology	Breast cancer	JCI Insight	Imlunestrant a next-generation oral SERD overcomes ESR1 mutant resistance in estrogen receptorpositive breast cancer
2025	CyteFinder	Liquid Biopsy	Oncology	Pancreatic Cancer	Cellular and Molecular Life Sciences	Portal venous circulating tumor cells as a biomarker for relapse prediction in resected pancreatic cancer
2025	Orion	Tissue	Immunology		Nature Immunology	ImmGenMaps, an open-source cartography of the immune system
2025	CyteFinder	Tissue	Infectious Disease	TB	BioRxiv	Multiomic analysis identifies suppressive myeloid cell populations in human TB granulomas
2025	CyteFinder	Tissue, TMA	Oncology	Lung Cancer	Clinical Cancer Research	Quantitative Protein Expression of Antibody-Drug Conjugate Targets in EGFR Mutated and Wild-Type Non-Small Cell Lung Cancer
2025	CyteFinder	Liquid Biopsy	Oncology	Brain Cancer	Nature Medicine	Neoadjuvant triplet immune checkpoint blockade in newly diagnosed glioblastoma
2025	CyteFinder	Tissue	Oncology	Brain Cancer	BioRxiv	A pathogenic subpopulation of human glioma associated macrophages linked to glioma progression
2025	Orion	Tissue, TMA	Oncology	Breast Cancer	BioRxiv	Swirling motion of breast cancer cells radially aligns collagen fibers to enable collective invasion
2025	Orion	Tissue	Immuno-oncology		BioRxiv	Macrophages restrict tumor permissiveness to immune infiltration by controlling local collagen topography through a Tcf4-Collagen3 fibrotic axis
2024	Orion	Tissue	Oncology	Lymphoma	Nature Immunology	Cutaneous T cell lymphoma atlas reveals malignant TH2 cells supported by a B cell-rich tumor microenvironment
2024	CyteFinder	Tissue	Oncology	Ovarian Cancer	Cancer Discovery	Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma
2024	CyteFinder	Tissue	Oncology	Ovarian Cancer	Cancer Cell	Chemotherapy induces myeloid-driven spatially confined T cell exhaustion in ovarian cancer
2024	CyteFinder	Tissue	Oncology	Ovarian Cancer	Cell	Ovarian cancer-derived IL-4 promotes immunotherapy resistance
2024	CyteFinder	Tissue	Oncology	Breast Cancer	NPJ Breast Cancer	Pure estrogen receptor antagonists potentiate capecitabine activity in ESR1-mutant breast cancer
2024	Orion	Tissue	Digital Pathology		Medical Image Analysis	Immunocto: a massive immune cell database auto-generated for histopathology
2024	Orion	Tissue	Immuno-oncology	Chronic Lymphocytic Leukemia	Nature Portfolio	Integrative multi-omics identifies regulatory and exhausted T cell types and novel immunotherapy targets in CLL lymph nodes
2024	CyteFinder	Tissue	Oncology	Breast Cancer	Nature Communications	Reciprocal antagonism of PIN1-APC/CCDH1 governs mitotic protein stability and cell cycle entry
2024	CyteFinder	Liquid Biopsy	NIPT	NIPT	Prenatal Diagnosis	Noninvasive single‐cell‐based prenatal genetic testing: A proof of concept clinical study
2024	Orion	Tissue	Aging		Nature Aging	Human skeletal muscle aging atlas
2024	CyteFinder	Tissue	Oncology	Breast Cancer	NPJ Breast Cancer	Qualification of a multiplexed tissue imaging assay and detection of novel patterns of HER2 heterogeneity in breast cancer
2024	CyteFinder	Liquid Biopsy	Oncology		Cancer Cytopatholoty	Detection of effusion tumor cells under different storage and processing conditions
2024	CyteFinder	Tissue	Oncology	Liposarcoma	Clinical Cancer Research	Phase II Study of Eribulin plus Pembrolizumab in Metastatic Soft Tissue Sarcomas: Clinical Outcomes and Biological Correlates.
2023	CyteFinder	Tissue	Immuno-oncology	Breast Cancer	Frontiers in Immunology	Antigen presentation deficiency, mesenchymal differentiation, and resistance to immunotherapy in the murine syngeneic CT2A tumor model
2023	CyteFinder	Liquid Biopsy	Oncology	Colorectal Cancer	Frontiers in Oncology	Circulating tumor cell enumeration, biomarker analyses, and kinetics in patients with colorectal cancer and other GI malignancies
2023	CyteFinder	Liquid Biopsy	Oncology	Colorectal Cancer	The Journal of Liquid Biopsy	Liquid biopsy kinetics and detection of ERBB2 amplification/HER2-positivity in refractory hepatocellular carcinoma
2023	Orion	Tissue	Oncology	Chronic Lymphocytic Leukemia	BioRxiv	High-dimensional single-cell definition of CLL T cells identifies Galectin-9 as novel immunotherapy target
2023	Orion	Tissue	Oncology	Colorectal Cancer	Nature Oncogene	Neoadjuvant botensilimab plus balstilimab response pattern in locally advanced mismatch repair proficient colorectal cancer
2023	Orion	Tissue	Oncology	Colorectal Cancer	Nature Cancer	High-plex immunofluorescence imaging and traditional histology of the same tissue section for discovering image-based biomarkers
2023	CyteFinder	Liquid Biopsy	Oncology	Breast Cancer	PNAS	Metastasis from the tumor interior and necrotic core formation are regulated by breast cancer-derived angiopoietin-like 7
2023	CyteFinder	Tissue	Oncology	Colorectal Cancer	Cell	Multiplexed 3D atlas of state transitions and immune interaction in colorectal cancer
2023	CyteFinder	Liquid Biopsy	Oncology		Frontiers in Oncology	Accurate isolation and detection of circulating tumor cells using enrichment-free multiparametric high resolution imaging
2022	CyteFinder	Liquid Biopsy	Oncology	Breast Cancer	Breast Cancer Research and Treatment	Circulating tumor cell detection: a prospective comparison between CellSearch and Rarecyte platforms in patients with progressive metastatic breast cancer.
2022	CyteFinder	Tissue	Oncology	Ovarian Cancer	Nature	Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer
2022	CyteFinder	Liquid Biopsy	Oncology		American Journal of Clinical Pathology	Clinical validation of a circulating tumor cell assay using density centrifugation and automated immunofluorescence microscopy
2022	CyteFinder	Tissue	Oncology	Melanoma	Cancer Discovery	The Spatial Landscape of Progression and Immunoediting in Primary Melanoma at Single-Cell Resolution
2022	CyteFinder	Liquid Biopsy	Oncology		Frontiers	Beyond circulating tumor cell enumeration: cell-based liquid biopsy to asses protein biomarkers and cancer genomics
2022	CyteFinder	Liquid Biopsy	Immuno-oncology	Prostate Cancer	International Journal of Molecular Sciences	Non-Invasive Profiling of Advanced Prostate Cancer via Multi-Parametric Liquid Biopsy and Radiomic Analysis
2022	CyteFinder	Liquid Biopsy	Oncology	NSCLC	Current issues in Molecular biology	Single Circulating-Tumor-Cell-Targeted Sequencing to Identify Somatic Variants in Liquid Biopsies in Non-Small-Cell Lung Cancer Patients
2021	CyteFinder	Liquid Biopsy	Oncology	Breast cancer	Cancers	Heterogeneity of Circulating Tumor Cell Neoplastic Subpopulations Outlined by Single-Cell Transcriptomics
2021	CyteFinder	Tissue	Oncology	GI cancer	Clinical Cancer Research	HAND1 and BARX1 Act as Transcriptional and Anatomic Determinants of Malignancy in Gastrointestinal Stromal Tumor
2021	CyteFinder	Liquid Biopsy	Oncology	NSCLC	Clinical Chemistry	Proficiency Testing to Assess Technical Performance for CTC-Processing and Detection Methods in CANCER-ID
2021	CyteFinder	Liquid Biopsy	Oncology	Breast Cancer	Molecular Cancer Research	N-Acetyl-L-cysteine Promotes Ex Vivo Growth and Expansion of Single Circulating Tumor Cells by Mitigating Cellular Stress Responses
2021	CyteFinder	Tissue	Immuno-oncology	Skin Cancer	Nat Medicine	Evolution of delayed resistance to immunotherapy in a melanoma responder
2021	CyteFinder	Liquid Biopsy	Oncology		Cancer Cytopathology	Identification and Characterization of Effusion Tumor Cells (ETCs) From Remnant Pleural Effusion Specimens
2020	CyteFinder	Tissue	Infectious disease	COVID-19	Science	SARS-CoV-2 infection protects against rechallenge in rhesus macaques
2020	CyteFinder	Tissue	Oncology	Ovarian Cancer	Nature Medicine	A single-cell landscape of high-grade serous ovarian cancer
2019	CyteFinder	Liquid Biopsy	NIPT	Cervical Cancer	Scientific Reports	A Rapid Method for Label-Free Enrichment of Rare Trophoblast Cells from Cervical Samples
2019	CyteFinder	Tissue	Immuno-oncology		Nature Protocol	Qualifying antibodies for image-based immune profiling and multiplexed tissue imaging
2019	CyteFinder	Liquid Biopsy	Oncology	Breast Cancer	Scientific Reports	PIC&RUN: An integrated assay for the detection and retrieval of single viable circulating tumor cells
2019	CyteFinder	Liquid Biopsy	Oncology	Breast Cancer	BMC Cancer	Circulating tumor cell investigation in breast cancer patient-derived xenograft models by automated immunofluorescence staining, image acquisition, and single cell retrieval and analysis
2018	CyteFinder	Liquid Biopsy	Oncology	Prostate Cancer	The Journal of Urology	Prostate Cancer Disseminated Tumor Cells are Rarely Detected in the Bone Marrow of Localized Patients Undergoing Radical Prostatectomy Across Multiple Rare Cell Detection Platforms
2018	CyteFinder	Tissue	Immuno-oncology		eLife	Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes
2018	CyteFinder	Tissue	Immuno-oncology	Skin Cancer	Cell	A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade
2018	CyteFinder	Liquid Biopsy	NIPT	NIPT	Prenatal Diagnosis	Reliable detection of subchromosomal deletions and duplications using cell‐based noninvasive prenatal testing
2016	CyteFinder	Liquid Biopsy	Oncology	Breast cancer	J. National Comprehensive Cancer Network	A Distributed Network for Intensive Longitudinal Monitoring in Metastatic Triple-Negative Breast Cancer
2016	CyteFinder	Liquid Biopsy	NIPT	NIPT	Prenatal Diagnosis	Evidence for feasibility of fetal trophoblastic cell-based noninvasive prenatal testing
2015	CyteFinder	Liquid Biopsy	Oncology		BMC Cancer	High-recovery visual identification and single-cell retrieval of circulating tumor cells for genomic analysis using a dual-technology platform integrated with automated immunofluorescence staining
	Platform		Classification

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