RarePlex® HER2/ER CTC Panel Kit

RarePlex – Staining Kits
Panel Kits – Enumeration | ARv7 | SYP | ARv7/SYP | HER2/ER | PD-L1
Developer Kits – 405/488
Custom Cell Detection Kits – Cell Discovery Kit
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RarePlex HER2/ER CTC Panel Kit

The RarePlex HER2/ER CTC Panel Kit (0901-VB) enables detection of human epidermal growth factor receptor 2 (HER2) and estrogen receptor (ER) expression by circulating tumor cells. HER2 and ER are important prognostic and therapeutic biomarkers in breast cancer. ER-signaling is the major driver of breast cancer proliferation and HER2 positive tumors are associated with aggressive disease. Ovarian, endometrial, gastric, and lung cancers are also known to have biomarker positivity for HER2 or HER2 and ER.

The HER2/ER Panel Kit includes all reagents needed to detect HER2, ER, CK/EpCAM, CD45, and nuclei on AccuCyte slides. Kit validation requirements were set to clinical standards and showed a high level of accuracy, repeatability, and inter-run precision. The HER2/ER Panel Kit is suitable for use in large, multi-center clinical trials where circulating tumor cell enumeration and phenotypic characterization data are required.

RareCyte’s deployable platform for circulating tumor cell analysis:

  • A clinical research laboratory can process blood to slides to result in their own lab
  • Platform produces accurate and highly reproducible results
  • Convenient pause points in workflow enable shipping between sites
  • Flexibility in sample processing – A site can process AccuCyte slides and/or perform staining and analysis
  • Leverage worldwide network of CROs
BT474 stained with the 0901-VB HER2/ER CTC Panel Kit.
Scale bar represents 10μm.
RarePlex® Assays: Design and Analytical Validation
Presented by Dr. Tad George, Sr. VP of Biology R&D
RarePlex Assays are sensitive, specific, and reproducible assays for CTC detection and biomarker expression. Gain insight into the principles RareCyte applies to its assay design and validation process in this 11 minute video.

Clinical breast cancer samples stained with the HER2/ER CTC Panel Kit.
Scale bar represents 10μm.
Clinical breast cancer samples were analyzed with the RarePlex HER2/ER CTC Panel Kit, a CyteFinder Instrument, and CyteMapper software. Results from a single clinical sample are shown. Mean fluorescence intensity thresholds for positivity are shown in the dashed copper lines and were defined by known model circulating tumor cells.